NLPR是AVP4-8的激动剂，可增加记忆受损大鼠脑内NGF基因的表达。

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity Pub Date : 1994-01-01

A W Zhou, J Guo, Y C Du

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摘要

对记忆受损大鼠口服四肽Asn-Leu-Pro-Arg (NLPR)可改善行为反应的获得和维持，并促进大脑中神经生长因子(NGF)的表达。提示NLPR可通过促进NGF基因表达改善记忆障碍，提示NLPR是治疗记忆障碍的潜在候选药物。

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NLPR, an agonist of AVP4-8, increases NGF gene expression in memory-impaired rat brain.

Oral administration of the tetrapeptide Asn-Leu-Pro-Arg (NLPR) to memory-impaired rats results in improved acquisition and maintenance of behavioural response and also facilitates nerve growth factor (NGF) expression in the brain. It is suggested that NLPR can ameliorate memory disability by promoting NGF gene expression, so implying that NLPR is a potential drug candidate for curing memory impairment.

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Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity

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