含有新型抗hiv药物ADRT的双链DNA的稳定性和构象。

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity Pub Date : 1996-01-01

N J Gibson, C M McKellar, T Brown

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引用次数: 0

摘要

抗hiv药物4′-叠氮胸苷(ADRT)已被磷酰胺法纳入DNA。通过CD光谱和紫外熔融分析表明，修饰核苷酸的存在对双相构象和稳定性的影响很小。

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The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.

The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.

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Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity

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