子宫内暴露于电离辐射诱导的小鼠淋巴样肿瘤的致瘤性变化。

K Lumniczky, S Antal, E Unger, E J Hidvégi, G Sáfrány
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引用次数: 5

摘要

我们研究了子宫内暴露于伽马辐射诱导的小鼠淋巴瘤的致癌改变。23%的肿瘤中myc癌基因的表达增加。ras癌基因和p53肿瘤抑制基因的表达变化不具有特征性。p53基因在肿瘤中发生突变的比例很低(12%)。未检测到Ras突变。在30%的肿瘤中发现p53位点的杂合性缺失(LOH),在23%的淋巴瘤中发现mts肿瘤抑制基因的LOH。在所研究的肿瘤中,多发癌性改变并不常见。自发和γ辐射诱导的淋巴瘤的致癌改变频率没有本质差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation.

We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to gamma-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and gamma-radiation-induced lymphomas.

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