蛋白激酶C的调节:脂质和蛋白质的故事。

Enzyme & protein Pub Date : 1996-01-01 DOI:10.1159/000468635
A F Quest
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引用次数: 56

摘要

蛋白激酶C (PKC)是一个丝氨酸/苏氨酸激酶家族,与多种激动剂引发的细胞内信号事件有关。目前,已经鉴定出11种哺乳动物PKC异构体,分为三组,钙依赖性,非钙依赖性和非典型异构体。所有成员的共同之处在于存在氨基端调控结构域,这使得激酶通过与羧基端催化结构域相互作用而失去活性。因此,细胞内PKC激活需要释放这种自身抑制,正如本文所总结的,这可能涉及与脂质和蛋白质的相互作用。此外,还讨论了翻译后PKC磷酸化事件,将PKC转化为激活状态所需的磷酸化事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulation of protein kinase C: a tale of lipids and proteins.

Protein kinase C (PKC) is a family of serine/threonine kinases implicated in intracellular signalling events triggered in response to a large variety of agonists. Currently, 11 mammalian PKC isoforms have been identified which are divided into three groups, the calcium-dependent, the non-calcium-dependent and the atypical isoforms. Common to all members is the presence of an aminoterminal regulatory domain, which renders the kinase inactive by interacting with the carboxyterminal catalytic domain. Thus, intracellular PKC activation requires the release of this autoinhibitory restraint, which, as this review summarizes, may involve both interactions with lipids and proteins. Furthermore, post-translational PKC phosphorylation events, required to convert PKC to an activation competent state, are discussed.

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