胃芬津的毒理学特征。1 .急性毒性(口服、皮下和静脉注射)。

Problemi na khigienata Pub Date : 1996-01-01
Zh Khalkova, Kh Zaĭkov, G Antov, A Mikhaĭlova, N Ivanova
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引用次数: 0

摘要

研究了保加利亚合成的抗溃疡药物“胃芬津”在大鼠“Wistar”和小白鼠“ICR”中口服、皮下和静脉应用的急性毒性。测定了主要毒理学参数(LD50、LD16、LD84等)。中毒的临床表现主要是由中枢和植物神经系统引起的症状。根据急性口服毒性参数测定,雄性大鼠LD50为665.0 mg。kg-1和女性-- -876 mg.kg-1)和Hodge & Stemer的分类是指胃芬津组的轻微毒性药物。皮下应用的LD50为938.0 mg。男性为Kg-1,男性为891.0 mg。Kg-1为雌性大鼠。静脉注射的LD50是50,1毫克。男性为1公斤,43.6毫克。Kg-1为雌性大鼠。三种应用方式的中毒致死危险系数均小于0.1,证实了其按上分类的地位。大鼠和小白鼠急性口服毒性指标性别差异不显著。无论男女,小白鼠对药物的作用似乎都比小白鼠更敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The toxicological characteristics of Gastrofenzin. I. Its acute toxicity (oral, subcutaneous and intravenous)].

The acute toxicity of the antiulcer drug "Gastrofenzin", synthesized in Bulgaria has been studied in oral, subcutaneous and intravenous application in white rats "Wistar" and white mice "ICR". The main toxicometric parameters (LD50, LD16, LD84 and others) have been determined. The clinical picture of intoxication is characterized mainly by symptoms deriving from in the central and vegetative nerve system. According to the parameters of acute oral toxicity (LD50 for male white rats is 665.0 mg.kg-1 and for female--876 mg.kg-1) and to the classification of Hodge & Stemer Gastrofenzin refers to the group of slightly toxic drugs. The LD50 in subcutaneous application is 938.0 mg.kg-1 for the male and 891.0 mg.kg-1 for the female rats. For the intravenous application LD50 is 50,1 mg.kg-1 for the male and 43.6 mg.kg-1 for the female rats. The coefficient of lethal intoxication danger is below 0.1 in the three ways of application which confirms its status according to the upper classification. A significant sex difference in the indicators of acute oral toxicity for the white rats and white mice has not been observed. The white mice of both sexes seem to be more sensitive to the drugs' effects than the white rats.

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