2,4-二氯苯氧乙酸通过哺乳诱导大鼠脑星形胶质细胞形成。

A Brusco, J P Saavedra, G García, P Tagliaferro, A M Evangelista de Duffard, R Duffard
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引用次数: 34

摘要

采用定量免疫组织化学方法比较25 d龄大鼠幼仔通过母乳接触2,4-二氯苯氧乙酸(2,4- d)后中脑、小脑和海马星形胶质细胞的免疫反应性。在海马和小脑的5 -羟色胺能核水平检测到神经胶质反应和极端星形胶质增生。以GFAP和S-100蛋白为特异性标志物,对反应性星形胶质细胞进行定量分析。研究表明,在2,4- d暴露的动物中,它们的数量、大小、过程数量和免疫染色密度显著增加。在生命最初几天暴露于2,4-二氯苯氧乙酸会改变星形胶质细胞结构,与先前描述的神经元变化平行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
2,4-dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain.

Comparison of astroglial immunoreactivity in mesencephalon, cerebellum, and hippocampus of 25-d-old rat pups exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through the mother's milk was made using a quantitative immunohistochemical analysis. A glial reaction was detected at the level of serotonergic nuclei and extreme astrogliosis in the hippocampus and cerebellum. A quantitative analysis of reactive astrocytes was performed by using GFAP and S-100 protein as specific markers. The study showed a significant increase in their number, size, number of processes, and density of immunostaining in 2,4-D-exposed animals. Exposure to 2,4-dichlorophenoxyacetic acid on the first days of life modifies the astroglial cytoarchitecture in parallel to previously described neuronal changes.

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