全身注射n -甲基- d -天冬氨酸诱导的非惊厥行为模式与脑腐胺浓度变化相关。

L Giménez-Llort, E Martínez, L Camón, N de Vera
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引用次数: 6

摘要

研究了n -甲基- d -天冬氨酸(NMDA) (150 mg/kg, ip)与脑多胺浓度对雄性Wistar大鼠行为和运动的影响。通过自动减法分析系统评估运动活动,以测量任何运动的持续时间和活力。非惊厥性nmda治疗大鼠表现出的行为改变根据行为成分的组成和顺序进行评估:低活动(模式A),部分刻板活动(模式B)和广义刻板活动(模式C)。在药物注射后8和24 h测量额叶皮层和海马多胺的浓度。在两个区域的腐胺浓度与运动活动之间发现了一种关系。此外,腐胺的浓度也与运动的活力相关。此外,脑额叶皮层和海马体中的腐胺浓度与行为模式相似。额皮质和海马区的组织学检查未发现任何损伤的证据。综上所述,系统性NMDA引起的部分或广泛的刻板活动诱导大脑中腐胺的增加,而与组织学损伤无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in brain putrescine concentration associated with nonconvulsant behavioral patterns induced by systemic N-methyl-D-aspartate injection.

The relationship between the behavioral effects and motor activity induced by N-methyl-D-aspartate (NMDA) (150 mg/kg, ip) and brain polyamine concentration was studied in male Wistar rats. Motor activity was evaluated by an automated subtraction analysis system to measure the duration and vigor of any kind of movement. The behavioral modifications exhibited by the nonconvulsant NMDA-treated rats were evaluated according to the composition and sequence of behavioral components as: hypoactivity (pattern A), partially stereotyped activity (pattern B), and generalized stereotyped activity (pattern C). The concentration of polyamines in the frontal cortex and hippocampus was measured 8 and 24 h after drug injection. A relationship was found between the concentration of putrescine in both regions and the motor activity. In addition, the concentrations of putrescine also correlated with the vigor of the movements performed. Moreover, the putrescine concentration in the frontal cortex and hippocampus paralleled the behavioral patterns. The histological examination of the frontocortical and hippocampal areas did not reveal any evidence of damage. In conclusion, partially or generalized stereotyped activity elicited by systemic NMDA administration induces an increase in putrescine in the brain not linked to histological damage.

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