核磁共振波谱:情绪障碍病理生理学的新见解

Jair C. Soares M.D., K. Ranga R. Krishnan M.D., Matcheri S. Keshavan M.D.
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引用次数: 67

摘要

磁共振波谱(MRS)是一种新型的无创脑化学研究方法。在本文中,我们回顾了在情绪障碍方面进行的初步研究。31P MRS研究提示双相情感障碍患者额叶和颞叶存在膜磷脂和能量代谢异常。1H MRS研究指出,单极和双相障碍患者基底神经节胆碱共振增加。与精神分裂症和其他神经精神疾病不同,情绪障碍与n -乙酰-天冬氨酸的减少无关。31P和1H MRS已开始用于研究电痉挛疗法的作用机制。19F和7Li MRS为精神药理学研究提供了治疗相关的新工具,可以测定精神药物的脑浓度。体内脑锂浓度的测量可能具有临床意义。虽然一些方法上的局限性仍然存在,但MRS提供的非侵入性和独特的神经化学见解为情绪障碍的神经生物学体内研究提供了极好的机会。抑郁症4:14-30(1996)。©1996 Wiley-Liss, Inc
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nuclear magnetic resonance spectroscopy: New insights into the pathophysiology of mood disorders

Magnetic Resonance Spectroscopy (MRS) is a novel non-invasive approach for investigation of in vivo brain neurochemistry. In this paper, we review the initial studies conducted in mood disorders. 31P MRS studies have suggested membrane phospholipid and energy metabolism abnormalities in the frontal and temporal lobes of bipolar patients. 1H MRS studies have pointed to increases in choline resonance in the basal ganglia of patients with unipolar and bipolar disorders. Mood disorders are not associated with reductions in N-acetyl-aspartate, unlike schizophrenia and other neuropsychiatric disorders. Both 31P and 1H MRS have begun to be used to investigate the mechanisms of action of ECT. 19F and 7Li MRS offer therapeutically relevant new tools for psychopharmacological investigation, allowing the determination of brain concentrations of psychotropic drugs. Measurement of in vivo brain lithium concentrations may have clinical relevance. While several methodological limitations persist, the noninvasiveness and the unique neurochemical insights provided by MRS offer an excellent opportunity for in vivo investigation of the neurobiology of mood disorders. Depression 4:14-30 (1996). © 1996 Wiley-Liss, Inc.

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