抗生素、细胞因子和内毒素:革兰氏阴性脓毒症的复杂和不断发展的关系。

D L Horn, S M Opal, E Lomastro
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引用次数: 0

摘要

目前有令人信服的实验证据表明,抗菌药物在细菌溶解过程中诱导革兰氏阴性菌释放内毒素。不同种类的抗菌素,特别是那些作用于细菌外膜的抗菌素,从革兰氏阴性菌释放的游离内毒素的量各不相同。尽管有这些体外证据,但抗生素诱导的内毒素释放的临床重要后果尚未得到一致的记录。在实际感染革兰氏阴性菌期间,宿主-病原体相互作用的复杂性可能解释了在体内证明这一现象的困难。这篇简短的综述分析了这些相互作用,并定义了抗生素诱导的内毒素释放可能被证明与临床相关的临床环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibiotics, cytokines, and endotoxin: a complex and evolving relationship in gram-negative sepsis.

Compelling experimental evidence now exists that antimicrobial agents induce the release of endotoxin from Gram-negative bacteria during the process of bacteriolysis. Different antimicrobial classes, particularly those which act upon the outer membrane of bacteria, vary in the amount of free endotoxin released from Gram-negative organisms. Despite this in vitro evidence, clinically important consequences of antibiotic-induced endotoxin release have yet to be consistently documented. Complexities in the host-pathogen interactions during actual infection with Gram-negative bacteria may account for the difficulties in demonstrating this phenomena in vivo. This brief review analyses these interactions and defines clinical settings where antibiotic-induced endotoxin release may prove to be clinically relevant.

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