{"title":"生物技术重组小鼠在生物安全性研究中的应用","authors":"T Inoue","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Number of transgenic and knock-out mice increased rapidly during the last decade. This review article describes a potential usefulness of transgenic and knock-out mice for biological safety research with respect to each toxicological category for safety evaluations, such as studies for carcinogenicity, general toxicology, genotoxicologic testing, and immuno-toxicological evaluations. In the carcinogenicity, a possible model required for a short-term study in carcinogenicity was discussed. Further, a couple of future subjects were focused specifically on the biotechnology-derived pharmaceuticals and the biotechnical recombinant-mice as a second generation, i.e. experimental mice with double or multiple gene-recombination. Those usefulnesses were also introduced briefly. Establishing the biotechnical recombinant-mice for each safety testing contributes not only to simplify and qualify the on-going evaluation system, but also to the traditional animal studies to be re-evaluated, so that the solutions may lead them to a future in vitro-alternative system much smoothly. For general references, historical reviews on the biotechnical recombination in experimental animals were also briefly introduced to elucidate a new broad area in developmental biology.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The use of biotechnological recombinant-mice in biological safety research].\",\"authors\":\"T Inoue\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Number of transgenic and knock-out mice increased rapidly during the last decade. This review article describes a potential usefulness of transgenic and knock-out mice for biological safety research with respect to each toxicological category for safety evaluations, such as studies for carcinogenicity, general toxicology, genotoxicologic testing, and immuno-toxicological evaluations. In the carcinogenicity, a possible model required for a short-term study in carcinogenicity was discussed. Further, a couple of future subjects were focused specifically on the biotechnology-derived pharmaceuticals and the biotechnical recombinant-mice as a second generation, i.e. experimental mice with double or multiple gene-recombination. Those usefulnesses were also introduced briefly. Establishing the biotechnical recombinant-mice for each safety testing contributes not only to simplify and qualify the on-going evaluation system, but also to the traditional animal studies to be re-evaluated, so that the solutions may lead them to a future in vitro-alternative system much smoothly. For general references, historical reviews on the biotechnical recombination in experimental animals were also briefly introduced to elucidate a new broad area in developmental biology.</p>\",\"PeriodicalId\":11656,\"journal\":{\"name\":\"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The use of biotechnological recombinant-mice in biological safety research].
Number of transgenic and knock-out mice increased rapidly during the last decade. This review article describes a potential usefulness of transgenic and knock-out mice for biological safety research with respect to each toxicological category for safety evaluations, such as studies for carcinogenicity, general toxicology, genotoxicologic testing, and immuno-toxicological evaluations. In the carcinogenicity, a possible model required for a short-term study in carcinogenicity was discussed. Further, a couple of future subjects were focused specifically on the biotechnology-derived pharmaceuticals and the biotechnical recombinant-mice as a second generation, i.e. experimental mice with double or multiple gene-recombination. Those usefulnesses were also introduced briefly. Establishing the biotechnical recombinant-mice for each safety testing contributes not only to simplify and qualify the on-going evaluation system, but also to the traditional animal studies to be re-evaluated, so that the solutions may lead them to a future in vitro-alternative system much smoothly. For general references, historical reviews on the biotechnical recombination in experimental animals were also briefly introduced to elucidate a new broad area in developmental biology.