实验性刚果锥虫感染家兔甲状腺状态及腺苷三磷酸酶活性

P.O. Lomo , D.W. Makawiti, V.N. Konji
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引用次数: 3

摘要

研究了锥虫感染对大鼠血浆三碘甲状腺原氨酸(T3)、甲状腺素(T4)水平和比值以及线粒体腺苷三磷酸酶(atp酶)活性的影响。实验采用性成熟新西兰白兔三组。1组为正常未感染的家兔,2组为实验性感染刚果锥虫的家兔,3组为感染后给予替代剂量甲状腺素的家兔。受感染的动物(第二组)T3和T4水平均迅速下降,但T3/T4比值升高,表明两种激素的产生或清除率存在差异。发现感染组的线粒体atp酶活性被抑制,而未感染(1组)和感染治疗的动物(2组)之间的atp酶活性没有显著差异。假设锥虫诱导的甲状腺功能减退可能在线粒体atp酶活性损伤中起作用,atp酶是能量代谢的关键酶。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroid status and adenosine triphosphataseactivity in experimental Trypanosoma congolense infection in rabbits

The effect of trypanosome infection on the plasma levels and ratios of tri-iodothyronine (T3) and thyroxine (T4) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. Three groups of sexually mature white New Zealand rabbits were used. Group 1 consisted of the normal non-infected rabbits, group 2 were experimentally infected with Trypanosoma congolense and group 3 were infected but given replacement doses of thyroxine. The infected animals (group 2) showed a rapid decline in both T3 and T4 but an increase in the T3/T4 ratio indicating differential production or clearance rates between the two hormones. The mitochondrial ATPase activity was found to be depressed in the infected group whereas there was no significant difference in the ATPase activity between the non-infected (group 1) and infected-treated animals (group 2). It is postulated that trypanosome induced hypothyroid status may play a role in the impairment of mitochondrial ATPase activity, a key enzyme in energy metabolism.

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