{"title":"实验性刚果锥虫感染家兔甲状腺状态及腺苷三磷酸酶活性","authors":"P.O. Lomo , D.W. Makawiti, V.N. Konji","doi":"10.1016/S0007-1935(96)80119-9","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of trypanosome infection on the plasma levels and ratios of tri-iodothyronine (T<sub>3</sub>) and thyroxine (T<sub>4</sub>) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. Three groups of sexually mature white New Zealand rabbits were used. Group 1 consisted of the normal non-infected rabbits, group 2 were experimentally infected with <em>Trypanosoma congolense</em> and group 3 were infected but given replacement doses of thyroxine. The infected animals (group 2) showed a rapid decline in both T<sub>3</sub> and T<sub>4</sub> but an increase in the T<sub>3</sub>/T<sub>4</sub> ratio indicating differential production or clearance rates between the two hormones. The mitochondrial ATPase activity was found to be depressed in the infected group whereas there was no significant difference in the ATPase activity between the non-infected (group 1) and infected-treated animals (group 2). It is postulated that trypanosome induced hypothyroid status may play a role in the impairment of mitochondrial ATPase activity, a key enzyme in energy metabolism.</p></div>","PeriodicalId":100203,"journal":{"name":"British Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0007-1935(96)80119-9","citationCount":"3","resultStr":"{\"title\":\"Thyroid status and adenosine triphosphataseactivity in experimental Trypanosoma congolense infection in rabbits\",\"authors\":\"P.O. Lomo , D.W. Makawiti, V.N. Konji\",\"doi\":\"10.1016/S0007-1935(96)80119-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of trypanosome infection on the plasma levels and ratios of tri-iodothyronine (T<sub>3</sub>) and thyroxine (T<sub>4</sub>) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. Three groups of sexually mature white New Zealand rabbits were used. Group 1 consisted of the normal non-infected rabbits, group 2 were experimentally infected with <em>Trypanosoma congolense</em> and group 3 were infected but given replacement doses of thyroxine. The infected animals (group 2) showed a rapid decline in both T<sub>3</sub> and T<sub>4</sub> but an increase in the T<sub>3</sub>/T<sub>4</sub> ratio indicating differential production or clearance rates between the two hormones. The mitochondrial ATPase activity was found to be depressed in the infected group whereas there was no significant difference in the ATPase activity between the non-infected (group 1) and infected-treated animals (group 2). It is postulated that trypanosome induced hypothyroid status may play a role in the impairment of mitochondrial ATPase activity, a key enzyme in energy metabolism.</p></div>\",\"PeriodicalId\":100203,\"journal\":{\"name\":\"British Veterinary Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0007-1935(96)80119-9\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Veterinary Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0007193596801199\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Veterinary Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0007193596801199","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Thyroid status and adenosine triphosphataseactivity in experimental Trypanosoma congolense infection in rabbits
The effect of trypanosome infection on the plasma levels and ratios of tri-iodothyronine (T3) and thyroxine (T4) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. Three groups of sexually mature white New Zealand rabbits were used. Group 1 consisted of the normal non-infected rabbits, group 2 were experimentally infected with Trypanosoma congolense and group 3 were infected but given replacement doses of thyroxine. The infected animals (group 2) showed a rapid decline in both T3 and T4 but an increase in the T3/T4 ratio indicating differential production or clearance rates between the two hormones. The mitochondrial ATPase activity was found to be depressed in the infected group whereas there was no significant difference in the ATPase activity between the non-infected (group 1) and infected-treated animals (group 2). It is postulated that trypanosome induced hypothyroid status may play a role in the impairment of mitochondrial ATPase activity, a key enzyme in energy metabolism.