K Kobayashi, O Inoue, Y Watanabe, H Onoe, B Långström
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引用次数: 20
摘要
采用正电子发射断层扫描技术研究了麻醉对恒河猴大脑多巴胺D2受体结合的影响。在控制氯胺酮或异氟醚麻醉下测定11c - n -甲基胡椒酮(NMSP)和11c -氯氯pride (RAC)的结合。异氟醚麻醉下纹状体中11C-NMSP的结合明显低于氯胺酮麻醉。11C-RAC的结合变化小于11C-NMSP。这些发现表明，麻醉剂引起的11C-NMSP或11C-RAC结合的变化不仅仅是由于内源性多巴胺竞争的变化。
Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of 11C-N-methylspiperone (NMSP) and 11C-raclopride (RAC) were measured under controlled ketamine or isoflurane anesthesia. The binding of 11C-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of 11C-RAC than of 11C-NMSP. These findings suggest that changes in 11C-NMSP or 11C-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.
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