24小时重复日粮的致突变性

Hiroshi Mano , Norio Shibuya , Hiroto Nakadaira Tatsuo Ohta , Teiji Ishizu , Osamu Yamazaki , Shuko Takagi , Kazuo Endoh , Masaharu Yamamoto , Tomio Hirohata
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引用次数: 1

摘要

为了阐明日本日粮的基因毒理学特征,对日粮样品进行了24 h重复诱变性研究。采用艾姆斯salmonila /微粒体法研究了蓝色人造丝提取物的致突变性。35份样品中有32份(91.4%)在S9混合物存在下对鼠伤寒沙门氏菌TA98表现出致突变性。诱变活性与烤鱼食用量(r = 0.517, p = 0.0021)和烤肉食用量(r = 0.494, p = 0.0036)呈极显著相关。在其他试验条件下,分别有6份(17.1%)、5份(14.3%)和8份(22.9%)样品对不含S9混合物的鼠伤寒沙门菌TA98、TA100和TA100不含S9混合物发生诱变。目前的研究结果表明,大量食用烤鱼和烤肉是日本饮食中诱变剂/致癌物的重要来源。然而,在目前的研究中,这些发现的生物学推断不能与癌症的发生有关,特别是胃癌,这是日本最常见的癌症形式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mutagenicity of 24-hour duplicate of Japanese diet

In order to elucidate the genotoxicological characteristics of the Japanese diet, the mutagenicity of 24-h duplicate of the diet samples were investigated. The mutagenicity of blue rayon extract was examined in the Ames Salmoneila/microsome assay. Thirty-two (91.4%) of 35 samples revealed mutagenicity toward Salmonella typhimurium TA98 in the presence of S9 mix. The mutagenic activities showed significant correlations with the consumption rates of broiled fish (r = 0.517, p = 0.0021) and broiled meat (r = 0.494, p = 0.0036). In other test conditions, 6 (17.1%), 5 (14.3%) and 8 (22.9%) samples were mutagenic to Salmonella typhimurium TA98 without S9 mix, TA100 with S9 mix and TA100 without S9 mix, respectively. Findings in the present study suggest that high consumption of broiled fish and broiled meat are important as the source of mutagens/carcinogens in the Japanese diet. In the present study, however, biological inference of these findings could not be made in relation to the occurrence of cancers, especially of the gastric cancer, which is the most prevalent form of cancer in Japan.

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