{"title":"体内小鼠骨髓细胞中lynoral(炔雌醇，雌激素)的遗传毒性","authors":"S.K. Shyama, M. Abdul Rahiman","doi":"10.1016/S0165-1218(96)00065-1","DOIUrl":null,"url":null,"abstract":"<div><p>The genotoxic effect of Lynoral (ethinyloestradiol, an oestrogen) was studied using mouse bone marrow cells treated in vivo, employing a chromosomal aberration assay and micronucleus test. The dose and time-yield effects of the sex hormonal drug were investigated. Lynoral failed to induce significant genetic damage in the bone marrow erythrocytes of mice, regarding chromosomal aberrations and micronuclei.</p></div>","PeriodicalId":100938,"journal":{"name":"Mutation Research/Genetic Toxicology","volume":"370 3","pages":"Pages 175-180"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0165-1218(96)00065-1","citationCount":"15","resultStr":"{\"title\":\"Genotoxicity of lynoral (ethinyloestradiol, an oestrogen) in mouse bone marrow cells, in vivo\",\"authors\":\"S.K. Shyama, M. Abdul Rahiman\",\"doi\":\"10.1016/S0165-1218(96)00065-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The genotoxic effect of Lynoral (ethinyloestradiol, an oestrogen) was studied using mouse bone marrow cells treated in vivo, employing a chromosomal aberration assay and micronucleus test. The dose and time-yield effects of the sex hormonal drug were investigated. Lynoral failed to induce significant genetic damage in the bone marrow erythrocytes of mice, regarding chromosomal aberrations and micronuclei.</p></div>\",\"PeriodicalId\":100938,\"journal\":{\"name\":\"Mutation Research/Genetic Toxicology\",\"volume\":\"370 3\",\"pages\":\"Pages 175-180\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0165-1218(96)00065-1\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/Genetic Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165121896000651\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/Genetic Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165121896000651","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genotoxicity of lynoral (ethinyloestradiol, an oestrogen) in mouse bone marrow cells, in vivo
The genotoxic effect of Lynoral (ethinyloestradiol, an oestrogen) was studied using mouse bone marrow cells treated in vivo, employing a chromosomal aberration assay and micronucleus test. The dose and time-yield effects of the sex hormonal drug were investigated. Lynoral failed to induce significant genetic damage in the bone marrow erythrocytes of mice, regarding chromosomal aberrations and micronuclei.
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