{"title":"卡波西肉瘤(KS)相关疱疹病毒及其在KS中的作用。","authors":"Y Chang, P S Moore","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.</p>","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"5 4","pages":"215-22"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.\",\"authors\":\"Y Chang, P S Moore\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.</p>\",\"PeriodicalId\":77176,\"journal\":{\"name\":\"Infectious agents and disease\",\"volume\":\"5 4\",\"pages\":\"215-22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious agents and disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious agents and disease","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.
Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.