卡波西肉瘤(KS)相关疱疹病毒及其在KS中的作用。

Infectious agents and disease Pub Date : 1996-10-01
Y Chang, P S Moore
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引用次数: 0

摘要

流行病学研究早就表明卡波西肉瘤(KS)是由性传播感染因子引起的。一种新的,可能是人类的疱疹病毒,卡波西肉瘤相关疱疹病毒(KSHV/HHV-8),已经通过基于序列的检测技术在艾滋病患者的KS病变中检测到。KSHV几乎存在于所有形式的KS病变中。该病毒是一种与猴疱疹病毒(HVS)最密切相关的rhadinvirus或γ -2 herpesvirus,它拥有几个可以改变宿主细胞环境的基因。KSHV已经在体外用来自与KSHV相关的第二种恶性肿瘤——体腔淋巴瘤(BCBL)的永生化B细胞系分离出来。迄今为止进行的流行病学研究表明,与其他人类疱疹病毒(HHV)不同,KSHV并非普遍存在。越来越多的证据表明,KSHV是一种强效的致癌疱疹病毒,可能是KS和BCBL的感染原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.

Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.

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