环氧复合固定剂的研究。

H W Sung, W H Cheng, I S Chiu, H L Hsu, S A Liu
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引用次数: 13

摘要

来源于胶原组织的生物假体在植入人体之前必须进行固定和消毒。临床上最常用的固定剂是戊二醛。然而,戊二醛明显改变组织僵硬和促进组织钙化的倾向是这种固定剂的公认缺点。为了解决戊二醛固定组织的不足,我们采用一种新型的环氧树脂固定物来固定生物假体。研究了不同环氧化合物对生物组织的固定率和交联密度的影响。这些环氧化合物的化学结构不同。以戊二醛为对照。通过测定固定指数和变性温度来测定固定组织的固定速率和交联密度。一般来说,环氧树脂固定的组织比戊二醛固定的组织柔韧性更好。此外,单功能环氧化合物固定的组织比多功能环氧化合物固定的组织更柔韧。随着pH和温度的升高,环氧化合物的固结率增加。然而,环氧化物官能团的数量似乎不影响环氧化合物的固定率。戊二醛的固定速率比环氧化合物快。此外,戊二醛固定的组织的交联密度大于环氧树脂固定的组织。此外,戊二醛或多功能环氧化合物固定的组织变性温度显著高于新鲜组织(p < 0.05),而单功能环氧化合物固定的组织变性温度在整个固定过程中基本保持不变(p > 0.05)。本研究结果可用于优化环氧树脂生物假体的固定工艺。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Studies on epoxy compound fixation.

Bioprostheses derived from collagenous tissues have to be fixed and subsequently sterilized before they can be implanted in humans. Clinically, the most commonly used fixative is glutaraldehyde. However, the tendency for glutaraldehyde to markedly alter tissue stiffness and promote tissue calcification are well-recognized drawbacks of this fixative. To address the deficiencies with the glutaraldehyde-fixed tissue, a new fixative, epoxy compound, was used to fix biological prostheses. The study was undertaken to investigate the fixation rates and crosslinking densities of biological tissues fixed with various epoxy compounds. These epoxy compounds are different in their chemical structures. Glutaraldehyde was used as a control. The fixation rates and crosslinking densities of the fixed tissues were determined by measuring their fixation indices and denaturation temperatures, respectively. Generally, the epoxy-fixed tissues were more pliable than the glutaraldehyde-fixed one. Furthermore, the tissues fixed with monofunctional epoxy compound were more pliable than those fixed with multifunctional epoxy compounds. With increasing pH or temperature, the fixation rate of epoxy compound increased. However, the number of epoxide functional groups did not seem to affect the fixation rate of the epoxy compound. The fixation rate of glutaraldehyde was faster than that of epoxy compounds. Additionally, the crosslinking density of the glutaraldehyde-fixed tissue was greater than that of the epoxy-fixed counterparts. Moreover, it was noted that the denaturation temperatures of the tissues fixed with glutaraldehyde or multifunctional epoxy compounds were significantly higher than the fresh ones (p < 0.05), while that fixed with monofunctional epoxy compound stayed roughly the same throughout the entire fixation process (p > 0.05). The results obtained in this study may be used to optimize the fixation process for developing bioprostheses fixed with epoxy compounds.

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