Double-stranded RNA viruses of Saccharomyces cerevisiae.

INFECTIOUS ELEMENTS OF SACCHAROMYCES CEREVISIAE 250 BIOLOGY OF THE YEAST dsRNA VIRUSES AND THE KILLER PHENOMENON 250 L-A VIRUS STRUCTURE: T 5 1 WITH 60 ASYMMETRIC Gag DIMERS 251 VIRAL REPLICATION CYCLES 251 L-A ENCODES Gag AND Gag-Pol 252 REPLICATION AND TRANSCRIPTION OF VIRAL RNA: IN VITRO SYSTEMS 254 TRANSLATION OF VIRAL mRNA 254 The SKI2,3,8 System Blocks the Translation of Non-Poly(A) mRNA 255 M1 Propagation Depends Critically on Free 60S Ribosomal Subunit Levels 256 Do SKI2, 3, and 8 Determine 60S Subunit Interaction with Poly(A)? 257 Gag Makes Decapitated Decoys To Distract the SKI1/XRN1 Exoribonuclease 257 Lethality of ski1 ski2 and ski1 ski3 double mutants 258 Gag-Pol Fusion Protein Formed by a 21 Ribosomal Frameshift: How and Why 258 Mechanism of 21 ribosomal frameshifting 258 How critical is the efficiency of frameshifting? 259 Chromosomal genes affecting the efficiency of frameshifting 259 Can 21 ribosomal frameshifting be used as a target of antiviral drugs? 259 POSTTRANSLATIONAL PROCESSING 259 MAK3 N-Acetyltransferase Modification of Gag Is Necessary for Assembly 259 Killer Preprotoxin Is Processed To Form Mature Toxin 260 KEX1 and KEX2 Processing Proteases and Mammalian Prohormone Processing 260 RNA PACKAGING: IN VITRO AND IN VIVO 260 Evidence for cis Packaging by L-A 260 Does Packaging Control Translation? 260 L-BC IS CLOSELY RELATED TO L-A 261 CONCLUSIONS AND PROSPECTS 261 REFERENCES 262