{"title":"谷氨酸受体亚型定位于发育中的纹状体斑块。","authors":"A Snyder-Keller, L C Costantini","doi":"10.1016/0165-3806(96)00070-3","DOIUrl":null,"url":null,"abstract":"<p><p>The distribution of glutamate receptors in the developing striatum of the rat was studied using antibodies specific to AMPA and NMDA subtypes. Immunocytochemistry revealed a greater density of GluR1, GluR2/3, NMDAR1, and NMDAR2A/2B receptors in patches that matched the patches of substance P-immunoreactive neurons and dopaminergic terminals. GluR1-immunoreactive patches were the most distinctive and were present already at embryonic day 19.</p>","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"94 2","pages":"246-50"},"PeriodicalIF":0.0000,"publicationDate":"1996-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-3806(96)00070-3","citationCount":"0","resultStr":"{\"title\":\"Glutamate receptor subtypes localize to patches in the developing striatum.\",\"authors\":\"A Snyder-Keller, L C Costantini\",\"doi\":\"10.1016/0165-3806(96)00070-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The distribution of glutamate receptors in the developing striatum of the rat was studied using antibodies specific to AMPA and NMDA subtypes. Immunocytochemistry revealed a greater density of GluR1, GluR2/3, NMDAR1, and NMDAR2A/2B receptors in patches that matched the patches of substance P-immunoreactive neurons and dopaminergic terminals. GluR1-immunoreactive patches were the most distinctive and were present already at embryonic day 19.</p>\",\"PeriodicalId\":9057,\"journal\":{\"name\":\"Brain research. Developmental brain research\",\"volume\":\"94 2\",\"pages\":\"246-50\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-3806(96)00070-3\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain research. Developmental brain research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/0165-3806(96)00070-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain research. Developmental brain research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0165-3806(96)00070-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Glutamate receptor subtypes localize to patches in the developing striatum.
The distribution of glutamate receptors in the developing striatum of the rat was studied using antibodies specific to AMPA and NMDA subtypes. Immunocytochemistry revealed a greater density of GluR1, GluR2/3, NMDAR1, and NMDAR2A/2B receptors in patches that matched the patches of substance P-immunoreactive neurons and dopaminergic terminals. GluR1-immunoreactive patches were the most distinctive and were present already at embryonic day 19.
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