{"title":"青蒿素和抗疟内过氧化物:从草药到靶向化疗。","authors":"S R Meshnick, T E Taylor, S Kamchonwongpaisan","doi":"10.1128/mr.60.2.301-315.1996","DOIUrl":null,"url":null,"abstract":"<p><p>Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.</p>","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"60 2","pages":"301-15"},"PeriodicalIF":0.0000,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239445/pdf/600301.pdf","citationCount":"41","resultStr":"{\"title\":\"Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.\",\"authors\":\"S R Meshnick, T E Taylor, S Kamchonwongpaisan\",\"doi\":\"10.1128/mr.60.2.301-315.1996\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.</p>\",\"PeriodicalId\":18499,\"journal\":{\"name\":\"Microbiological reviews\",\"volume\":\"60 2\",\"pages\":\"301-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239445/pdf/600301.pdf\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbiological reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1128/mr.60.2.301-315.1996\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiological reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/mr.60.2.301-315.1996","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.
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