A. Matsuoka , K. Yamakage , H. Kusakabe , S. Wakuri , M. Asakura , T. Noguchi , T. Sugiyama , H. Shimada , S. Nakayama , Y. Kasahara , Y. Takahashi , K.F. Miura , M. Hatanaka , M. Ishidate Jr. , T. Morita , K. Watanabe , M. Hara , K. Odawara , N. Tanaka , M. Hayashi , T. Sofuni
{"title":"九种小鼠淋巴瘤试验“独特阳性”NTP致癌物对染色体畸变诱导的再评价","authors":"A. Matsuoka , K. Yamakage , H. Kusakabe , S. Wakuri , M. Asakura , T. Noguchi , T. Sugiyama , H. Shimada , S. Nakayama , Y. Kasahara , Y. Takahashi , K.F. Miura , M. Hatanaka , M. Ishidate Jr. , T. Morita , K. Watanabe , M. Hara , K. Odawara , N. Tanaka , M. Hayashi , T. Sofuni","doi":"10.1016/S0165-1218(96)90029-4","DOIUrl":null,"url":null,"abstract":"<div><p>In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) ‘unique positive’ NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloromethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). These six chemicals, therefore, are not uniquely positive in the MLA. The difference between the NTP results and ours might be due to the use of diffent cell lines and protocols, and in some cases, to different interpretations of polyploidy. The remaining three chemicals, ebzykl acetate, cinnamyl anthranilate and trichloroethylene, were negative in this study.</p></div>","PeriodicalId":100938,"journal":{"name":"Mutation Research/Genetic Toxicology","volume":"369 3","pages":"Pages 243-252"},"PeriodicalIF":0.0000,"publicationDate":"1996-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0165-1218(96)90029-4","citationCount":"55","resultStr":"{\"title\":\"Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay ‘unique positive’ NTP carcinogens\",\"authors\":\"A. Matsuoka , K. Yamakage , H. Kusakabe , S. Wakuri , M. Asakura , T. Noguchi , T. Sugiyama , H. Shimada , S. Nakayama , Y. Kasahara , Y. Takahashi , K.F. Miura , M. Hatanaka , M. Ishidate Jr. , T. Morita , K. Watanabe , M. Hara , K. Odawara , N. Tanaka , M. Hayashi , T. Sofuni\",\"doi\":\"10.1016/S0165-1218(96)90029-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) ‘unique positive’ NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloromethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). These six chemicals, therefore, are not uniquely positive in the MLA. The difference between the NTP results and ours might be due to the use of diffent cell lines and protocols, and in some cases, to different interpretations of polyploidy. The remaining three chemicals, ebzykl acetate, cinnamyl anthranilate and trichloroethylene, were negative in this study.</p></div>\",\"PeriodicalId\":100938,\"journal\":{\"name\":\"Mutation Research/Genetic Toxicology\",\"volume\":\"369 3\",\"pages\":\"Pages 243-252\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0165-1218(96)90029-4\",\"citationCount\":\"55\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/Genetic Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165121896900294\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/Genetic Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165121896900294","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay ‘unique positive’ NTP carcinogens
In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) ‘unique positive’ NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloromethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). These six chemicals, therefore, are not uniquely positive in the MLA. The difference between the NTP results and ours might be due to the use of diffent cell lines and protocols, and in some cases, to different interpretations of polyploidy. The remaining three chemicals, ebzykl acetate, cinnamyl anthranilate and trichloroethylene, were negative in this study.
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