正常结肠、炎症性肠病和结肠腺癌中黏液的组织化学改变。

The Histochemical Journal Pub Date : 1995-11-01
D A Owen, P E Reid
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引用次数: 0

摘要

使用特定的组织化学技术,在患有多种大肠疾病的个体和对照人群中研究了结肠粘液中唾液酸邻酰基取代的丢失。发现的变化包括侧链取代的局部或场(弥漫性)损失,在所有研究组中定性相似。使用各种假设对结果进行了统计检验,这些假设认为o-酰基取代的现场和/或局部损失可能是异常的,也可能是正常的变体。在正常男性和女性之间以及0-29岁和30-80岁的正常个体之间,替换率没有统计学上的显著差异。正常个体的升、降结肠与癌患者的非肿瘤性粘膜之间存在显著差异。正常降结肠与降结肠癌患者之间也存在显著差异。这些差异似乎不太可能是由非特异性因素造成的,因为在大多数假设中,结肠癌和炎症性肠病患者的结肠癌之间也存在差异。与其他研究人员的工作一致,o-乙酰化的局灶性丧失似乎可能是由获得性基因突变引起的。目前尚不清楚这是否在致癌过程中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histochemical alterations of mucin in normal colon, inflammatory bowel disease and colonic adenocarcinoma.

Loss of sialic acid o-acyl substitutions in colonic mucus was studied using specific histochemical techniques in individuals with a variety of large-bowel diseases and in a control population. Changes found included a focal or field (diffuse) loss of side-chain substitutions which were qualitatively similar in all groups studied. The results were tested statistically using a variety of assumptions that field and/or focal loss of o-acyl substitution may be either abnormal or a normal variant. No statistically significant differences in the prevalence of substitutions were detected between normal males and females or between normal individuals aged 0-29 years and 30-80 years. Significant differences were found between ascending and descending colon in both normal individuals and in the non-neoplastic mucosa of patients with cancer. There were also significant differences between the normal descending colon and cases with cancer of the descending colon. These differences seem unlikely to be due to non-specific factors, since for most assumptions there were also differences between colons containing cancer and those from patients with inflammatory bowel disease. In agreement with the work of other investigators, it seems likely that focal loss of o-acetylation results from an acquired gene mutation. It is not clear whether or not this plays a role in carcinogenesis.

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