原发性动脉高血压患者血浆内皮素水平升高。

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1996-01-01

A Amoroso, M F Cossu, A Mariotti, F Guido, G M Ferri, F G De Rosa, G Sportelli

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引用次数: 0

摘要

内皮素-1 (ET-1)是一种内皮来源的血管收缩肽。在这项研究中，作者测量了25名受试者(15名原发性高血压患者和10名正常人)血浆内皮素-1水平。高血压患者血浆ET-1浓度明显高于正常人(2.18 +/- 1.07 vs. 1.36 +/- 0.40 pg/ml, p < 0.02)。血浆精氨酸抗利尿素、肾素活性和醛固酮浓度在高血压组和正常组之间无显著差异。这些数据提示ET-1可能参与了高血压的发生或维持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Increased plasma levels of endothelin in patints with essential arterial hypertension].

Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictive peptide. In this study the Authors measured in 25 subjects (15 with essential hypertension and 10 normal) plasma levels of endothelin-1. Patients with hypertension had significantly higher plasma ET-1 concentration than normal subjects (2.18 +/- 1.07 vs. 1.36 +/- 0.40 pg/ml, p < 0.02). Plasma arginine vasopressin, renin activity and aldosterone concentration did not show significant differences between hypertensive and normotensive subjects. These data suggest that ET-1 may be involved in the development or maintenance of hypertension.

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Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques

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