{"title":"水不溶性羧酸的13C-NMR解离常数。中胆红素- xiii α和中胆红素- xiii α的pK(a)s。","authors":"D A Lightner, D L Holmes, A F McDonagh","doi":"10.1007/BF01969747","DOIUrl":null,"url":null,"abstract":"<p><p>High-field 13C-NMR of 13C-enriched compounds in dilute aqueous d6-Me2-SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be 4.2 and 4.9, much lower values than reported recently for bilirubin, and of mesobiliverdin-XIII alpha to be 3.9 and 5.3.</p>","PeriodicalId":12087,"journal":{"name":"Experientia","volume":"52 6","pages":"639-42"},"PeriodicalIF":0.0000,"publicationDate":"1996-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01969747","citationCount":"3","resultStr":"{\"title\":\"Dissociation constants of water-insoluble carboxylic acids by 13C-NMR. pK(a)s of mesobiliverdin-XIII alpha and mesobilirubin-XIII alpha.\",\"authors\":\"D A Lightner, D L Holmes, A F McDonagh\",\"doi\":\"10.1007/BF01969747\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>High-field 13C-NMR of 13C-enriched compounds in dilute aqueous d6-Me2-SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be 4.2 and 4.9, much lower values than reported recently for bilirubin, and of mesobiliverdin-XIII alpha to be 3.9 and 5.3.</p>\",\"PeriodicalId\":12087,\"journal\":{\"name\":\"Experientia\",\"volume\":\"52 6\",\"pages\":\"639-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF01969747\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experientia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF01969747\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experientia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01969747","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
在稀水d6-Me2-SO溶液中富集13c的化合物的高场13C-NMR为测定难溶羧酸的pK(a)s提供了一种简单、准确的方法。利用这种方法，我们发现中胆红素- xiii α的pK(a)s为4.2和4.9，远低于最近报道的胆红素，中胆红素- xiii α的pK(a)s为3.9和5.3。
Dissociation constants of water-insoluble carboxylic acids by 13C-NMR. pK(a)s of mesobiliverdin-XIII alpha and mesobilirubin-XIII alpha.
High-field 13C-NMR of 13C-enriched compounds in dilute aqueous d6-Me2-SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be 4.2 and 4.9, much lower values than reported recently for bilirubin, and of mesobiliverdin-XIII alpha to be 3.9 and 5.3.
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