海马结构局部注射组胺对大鼠单向主动回避反应恢复的影响。

E O Alvarez, A M Banzan
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引用次数: 19

摘要

研究海马局部注入组胺(HA)对大鼠记忆机制的影响。采用超声40 kHz正弦波预测电击时的单向主动回避响应作为实验模型。学习过程包括把动物放在一个有两个隔间的笼子里,让它们学会在听到超声波声后逃到安全隔间,预料到脚会受到电击。在获得条件回避反应后,将动物植入微注射管,并向海马注射1微升生理盐水或增加剂量的组胺(9、22.5、45和90 nmol)。在治疗前(PRE)和治疗后(POST)的4个试验中,测量条件回避反应的百分比(% CAR)和逃避潜伏期(LT)。结果表明,透明质酸显著提高肝细胞移植率,且这种作用具有明显的剂量依赖性。% CAR也受到影响,咪唑胺可显著抑制评分。结果表明,HA可能参与海马的记忆恢复过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of localized histamine microinjections into the hippocampal formation on the retrieval of a one-way active avoidance response in rats.

The possible role of histamine (HA) locally applied into the hippocampus on memory mechanisms of the rats was studied. The acquisition of a one-way active avoidance response to an ultrasonic 40 kHz sinus-wave tone anticipating an electric shock was used as experimental model. Learning sessions consisted in placing animals into a two compartment cage were they learnt to escape to the safe compartment after an ultrasonic tone anticipating an electric feet shock. After acquiring the conditioned avoidance response, animals were implanted with microinjection cannulae and injected with 1 microliter of saline, or increasing doses of histamine (9, 22.5, 45, and 90 nmol) into the hippocampus. In the experimental sessions, 4 trials before (PRE) and 4 trials afterward treatment (POST), the percentage of conditioned avoidance responses (% CAR) and the latency time to escape (LT) were measured. Results showed that HA increased significantly the LT and this effect was grossly dose-dependent. % CAR was also affected and the score was significantly inhibited by the imidazolamine administration. Results suggest that HA may be involved in memory retrieval processes in the hippocampus.

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