雄激素作用的遗传调控。

The Prostate. Supplement Pub Date : 1996-01-01

P J Kallio, J J Pakvimo, O A Janne

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引用次数: 0

摘要

雄激素受体(androgen receptor, AR)属于核受体超家族，通过复杂的遗传机制指导不同靶组织的发育和生理功能。在与其同源激素相互作用后，AR通过与特定DNA元件和/或蛋白质的关联激活或抑制基因转录。这篇综述简要地总结了我们目前对雄激素作用的看法，特别强调了可能调节反应的遗传因素。

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Genetic regulation of androgen action.

The androgen receptor (AR) belongs to the superfamily of nuclear receptors that employ complex genetic mechanisms to guide the development and physiological functions of different target tissues. Upon interaction with its cognate hormone, AR activates or represses gene transcription through association with specific DNA elements and/or proteins. This review summarize briefly our current view of androgen action, with a special emphasis on genetic factors that may modulate the response.

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The Prostate. Supplement

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