未治疗的急性精神分裂症患者脑电反应性和脑电活动的频谱参数和维数复杂性测量。

M Koukkou, D Lehmann, A Federspiel, M C Merlo
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引用次数: 17

摘要

我们的方法,以使用脑电图研究,以了解精神分裂症症状的发病机制提出。对正常行为组织背后的启发式和多因素脑心理生物学机制的基本假设进行了描述和使用,以便通过脑电图测量来制定和检验关于精神分裂症行为发病机制的假设。总结了基于频谱参数和“混沌”维数(相关维数)对脑电活动和脑电反应性(记忆驱动、自适应、非单一定向反应的脑电成分)的研究结果。两种分析方法都表明,在从未治疗过的首发精神分裂症患者中存在异常的脑功能组织,在模型框架内,这表明症状发病机制的共同点是工作记忆的偏差,其性质是功能性的,而不是结构性的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EEG reactivity and EEG activity in never-treated acute schizophrenics, measured with spectral parameters and dimensional complexity.

Our approaches to the use of EEG studies for the understanding of the pathogenesis of schizophrenic symptoms are presented. The basic assumptions of a heuristic and multifactorial model of the psychobiological brain mechanisms underlying the organization of normal behavior is described and used in order to formulate and test hypotheses about the pathogenesis of schizophrenic behavior using EEG measures. Results from our studies on EEG activity and EEG reactivity (= EEG components of a memory-driven, adaptive, non-unitary orienting response) as analyzed with spectral parameters and "chaotic" dimensionality (correlation dimension) are summarized. Both analysis procedures showed a deviant brain functional organization in never-treated first-episode schizophrenia which, within the framework of the model, suggests as common denominator for the pathogenesis of the symptoms a deviation of working memory, the nature of which is functional and not structural.

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