微透析作为评估自发性高血压大鼠脂肪组织间质去甲肾上腺素水平的工具。

Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma Pub Date : 1995-01-01

E Bergamaschi, A Cabassi, A Mutti, I Franchini, A Borghetti

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摘要

应用微透析技术研究自发性高血压(SHR, n = 6)和正常Wistar-Kyoto (WKY, n = 6)大鼠白色脂肪组织中去甲肾上腺素(NE)的代谢。SHR的间质NE平均浓度比WKY高得多(平均+/- SEM: 980.9 +/- 125.6 pg/ml vs 520.7 +/- 96.1 pg/ml;P = 0.01)。这些结果与周围交感神经末梢的持续流出可能在维持动脉高血压中起作用的假设是一致的。由于其低侵入性，微透析技术允许在有意识和自由活动的动物中连续监测NE的细胞外水平。

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Microdialysis as a tool to assess interstitial norepinephrine levels in adipose tissue of spontaneously hypertensive rats.

The microdialysis technique was applied to the study of norepinephrine (NE) metabolism in white adipose tissue of spontaneously hypertensive (SHR, n = 6) and normotensive Wistar-Kyoto (WKY, n = 6) rats. Mean concentrations of interstitial NE were much higher in SHR as compared to WKY (mean +/- SEM: 980.9 +/- 125.6 pg/ml vs 520.7 +/- 96.1 pg/ml; p = 0.01) over the 180 min experimental period. These results are consistent with the hypothesis that sustained outflow from nerve endings of the peripheral sympathetic system may play a role in the maintenance of arterial hypertension. Owing to its low invasiveness, the microdialysis technique allows to continuously monitor NE extracellular levels in conscious and freely-moving animals.

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Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma

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