Ben H. Hoiting, René Kuipers, Carolina R.S. Elzinga, Johan Zaagsma, Herman Meurs
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Feedforward control of agonist-induced Ca2+ signalling by protein kinase C in airway smooth muscle cells
In isolated bovine tracheal smooth muscle cells, the potent and specific protein kinase C inhibitor GF 109203X caused an inhibition of methacholine-and histamine-induced Ca2+ mobilization and influx, indicating for the first time that protein kinase C activation induced by contractile agonists exerts a positive feedforward control of Ca2+ signalling by these agonists.
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