一氧化氮在生理学和病理学上的应用。

The Histochemical Journal Pub Date : 1995-10-01
B J Whittle
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引用次数: 0

摘要

一氧化氮(NO)可以发挥多种生物作用。一氧化氮是由l -精氨酸通过钙依赖酶(NO合成酶)形成的,在调节血管张力和完整性方面起着关键的生理作用。一氧化氮是由一氧化氮合成酶的组成型神经元异构体形成的,同样发挥着重要的神经调节剂作用。相比之下,诱导一氧化氮合酶的钙非依赖性异构体可以产生高水平的一氧化氮。一氧化氮的过量产生可引起低血压,如在感染性休克中观察到的,并可发挥细胞毒性作用,导致组织损伤和炎症。因此,这种可诱导异构体的选择性抑制剂在许多疾病状态中具有治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nitric oxide in physiology and pathology.

Nitric oxide (NO) can exert a multitude of biological actions. NO, formed from L-arginine by a calcium-dependent enzyme (NO synthase) plays a key physiological role in regulating vascular tone and integrity. NO, formed by a constitutive neuronal isoform of NO synthase, likewise plays an important neuromodulator role. By contrast, high levels of NO can be generated following induction of a calcium-independent isoform of NO synthase. This excessive production of NO can provoke hypotension such as that observed in septic shock, and can exert cytotoxic actions leading to tissue injury and inflammation. Selective inhibitors of this inducible isoform thus have therapeutic potential in a number of disease states.

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