{"title":"大鼠右心房肌醇磷酸对凝血酶的反应不同于对去甲肾上腺素的反应","authors":"Elizabeth A. Woodcock, Kim A. Lambert","doi":"10.1016/0922-4106(95)90146-9","DOIUrl":null,"url":null,"abstract":"<div><p>Addition of thrombin to isolated [<sup>3</sup>H]inositol-labelled rat right atria stimulated the release of <sup>3</sup>H-labelled inositol phosphates. The thrombin response was smaller than the response to noradrenaline and generated a different spectrum of inositol phosphates. Unlike the inositol phosphate response to noradrenaline, the thrombin response was inhibited by pertussis toxin treatment and by the phospholipase C inhibitor U-73122 (1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2 ,5-dione). The data indicate that the thrombin stimulation involves different G-proteins and phospholipase C isoforms from those which couple <em>α</em><sub>1</sub>-adrenoceptors in the myocardium.</p></div>","PeriodicalId":100502,"journal":{"name":"European Journal of Pharmacology: Molecular Pharmacology","volume":"291 2","pages":"Pages 213-216"},"PeriodicalIF":0.0000,"publicationDate":"1995-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0922-4106(95)90146-9","citationCount":"9","resultStr":"{\"title\":\"The inositol phosphate response to thrombin in rat right atria differs from the response to noradrenaline\",\"authors\":\"Elizabeth A. Woodcock, Kim A. Lambert\",\"doi\":\"10.1016/0922-4106(95)90146-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Addition of thrombin to isolated [<sup>3</sup>H]inositol-labelled rat right atria stimulated the release of <sup>3</sup>H-labelled inositol phosphates. The thrombin response was smaller than the response to noradrenaline and generated a different spectrum of inositol phosphates. Unlike the inositol phosphate response to noradrenaline, the thrombin response was inhibited by pertussis toxin treatment and by the phospholipase C inhibitor U-73122 (1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2 ,5-dione). The data indicate that the thrombin stimulation involves different G-proteins and phospholipase C isoforms from those which couple <em>α</em><sub>1</sub>-adrenoceptors in the myocardium.</p></div>\",\"PeriodicalId\":100502,\"journal\":{\"name\":\"European Journal of Pharmacology: Molecular Pharmacology\",\"volume\":\"291 2\",\"pages\":\"Pages 213-216\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0922-4106(95)90146-9\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Pharmacology: Molecular Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0922410695901469\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmacology: Molecular Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0922410695901469","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The inositol phosphate response to thrombin in rat right atria differs from the response to noradrenaline
Addition of thrombin to isolated [3H]inositol-labelled rat right atria stimulated the release of 3H-labelled inositol phosphates. The thrombin response was smaller than the response to noradrenaline and generated a different spectrum of inositol phosphates. Unlike the inositol phosphate response to noradrenaline, the thrombin response was inhibited by pertussis toxin treatment and by the phospholipase C inhibitor U-73122 (1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2 ,5-dione). The data indicate that the thrombin stimulation involves different G-proteins and phospholipase C isoforms from those which couple α1-adrenoceptors in the myocardium.
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