甲羟戊酸途径和类异戊二烯调节人支气管肌细胞增殖

Teresa Viganò , Alicia Hernandez , Alberto Corsini , Agnese Granata , Pierangelo Belloni , Remo Fumagalli , Rodolfo Paoletti , Giancarlo Folco
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引用次数: 21

摘要

通过观察辛伐他汀(甲戊酸合成限速酶3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂)的作用,探讨甲戊酸和香叶香叶醇对培养的人支气管肌细胞增殖的控制作用。辛伐他汀抑制人支气管平滑肌细胞生长呈浓度依赖性,IC50值为0.97±0.1 μM。Mevalonate (100 μM)和geranylgeraniol (5 μM)在其最高无毒浓度下,将细胞增殖恢复到控制水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation

The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97±0.1 μM. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.

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