以合成多离子为基础构建人工免疫原和疫苗的分子基础。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1995-09-01 DOI:10.2500/108854195778702648

R M Khaitov

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引用次数: 2

摘要

综述了合成多离子对免疫发生作用的分子和细胞机制。研究多离子免疫刺激剂的主要性质和细胞对这些刺激剂作用的反应的结果已被用于构建具有增强免疫原性的人工抗原-多离子复合物。分析了用细菌或病毒抗原构建的这种大分子复合物的免疫特性。

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Molecular bases for the construction of artificial immunogens and vaccines based on synthetic polyions.

The molecular and cellular mechanisms of action of synthetic polyions on immunogenesis are reviewed. The results of studies of principal properties of polyionic immunostimulators and of the cell responses to the action of these stimulants have been used to construct artificial antigen-polyion complexes with enhanced immunogenic properties. The immunizing properties of such macromolecular complexes, constructed with the use of bacterial or viral antigens, are analyzed.

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Allergy proceedings : the official journal of regional and state allergy societies

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