乳腺癌患者血清CA15-3与CEA的比较。

M F Hou, T J Huang, J S Hsieh, Y S Huang, C J Huang, H M Chan, J Y Wang, Y L Chen, S B Jong, C C Yang
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引用次数: 0

摘要

制备了针对人乳脂球膜抗原115D8和乳腺癌抗原DF3的单克隆抗体CA15-3。放射免疫法测定CA15-3,酶免疫法测定CEA。正常对照32例,CA15-3平均值为11.5 +/- 3.0 u/ml,范围为7.9 ~ 16.9 u/ml。我们比较了121例经组织学证实的乳腺癌患者血清CA15-3和CEA的水平。CA15-3水平高于25 u/ml, CEA水平高于5 ng/ml为阳性。121例患者中有31例CA15-3水平升高(敏感性为25.6%),21例CEA水平阳性(敏感性为17.4%)。92例乳腺癌患者(76%)没有转移性疾病。本组CA15-3敏感性为7.6%,CEA敏感性为6.5%。CA15-3的平均值为15.1 +/- 6.6 u/ml, CEA的平均值为1.78 +/- 2.47 ng/ml。29例(24%)有转移性疾病。本组CA15-3敏感性为82.8%,CEA敏感性为51.7% (P < 0.05)。CEA CA15-3的平均值为147.5 +/- 175.9 u/ml和16.9 +/- 24.0 ng/ml。关于两种肿瘤标志物与临床病程的相关性,转移性乳腺癌患者的CA15-3水平明显高于CEA水平。这一结果表明,CA15-3在转移性乳腺癌的检测和监测中更敏感、更特异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of serum CA15-3 and CEA in breast cancer.

The monoclonal antibodies CA15-3 were developed against the two antigens 115D8 of the human milk fat globule membrane and DF3 of breast cancer. CA15-3 was assayed radioimmunologically and CEA was analysed using the enzyme immunoassay. Normal control was achieved in 32 healthy women, the mean values for CA15-3 were 11.5 +/- 3.0 u/ml, range from 7.9 to 16.9 u/ml. We compared serum levels of CA15-3 and CEA in 121 patients with histologically proved breast carcinoma. CA15-3 levels above 25 u/ml and CEA levels above 5 ng/ml were considered positive values. 31 of 121 patients studied had elevated CA15-3 levels (sensitivity: 25.6%) and 21 of 121 patients had positive CEA levels (sensitivity 17.4%). 92 of the breast cancer patients (76%) did not have metastatic disease. In this group CA15-3 sensitivity was 7.6%, while CEA sensitivity was 6.5%. Mean values were 15.1 +/- 6.6 u/ml for CA15-3 and 1.78 +/- 2.47 ng/ml for CEA. 29 patients (24%) had metastatic disease. In this group, CA15-3 sensitivity was 82.8% and CEA sensitivity was 51.7% (P < 0.05). Mean values for CA15-3 were 147.5 +/- 175.9 u/ml and 16.9 +/- 24.0 ng/ml of CEA. With regard to the correlation of two tumor markers with clinical course patients had significantly higher levels of CA15-3 than of CEA in metastatic breast cancer. This result suggests CA15-3 to be the more sensitive and more specific of the two for metastatic breast cancer detection and monitoring.

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