胰岛素受体酪氨酸激酶活性的变化与二甲双胍治疗2型糖尿病相关。

Diabete & metabolisme Pub Date : 1995-10-01
R F Santos, R Nomizo, B L Wajhenberg, G M Reaven, S Azhar
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引用次数: 0

摘要

本研究旨在确定二甲双胍对非胰岛素依赖型(2型)糖尿病患者血糖控制和红细胞胰岛素受体酪氨酸激酶活性的影响。在糖尿病临床中心门诊患者中对二甲双胍治疗高血糖合并2型糖尿病患者的疗效进行了病例对照研究。研究人群包括14例高血糖不受饮食控制的2型糖尿病患者(5男9女)。患者接受二甲双胍850毫克治疗,每日两次,疗程2个半月。二甲双胍治疗10周后,空腹血糖浓度从8.9 mmol/L降至6.4 mmol/L (p < 0.001),与口服葡萄糖负荷显著降低(p < 0.001)的血糖和胰岛素浓度相关。此外,在二甲双胍治疗后,空腹血浆甘油三酯和胆固醇浓度均显著降低(p < 0.001)。红细胞胰岛素受体结合与二甲双胍治疗没有变化,但基础和胰岛素刺激的溶解红细胞胰岛素受体酪氨酸激酶活性在二甲双胍治疗10周后均显著升高。由此可见,胰岛素刺激的酪氨酸激酶活性的增加有助于改善与二甲双胍治疗2型糖尿病相关的葡萄糖、胰岛素和脂蛋白代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in insulin receptor tyrosine kinase activity associated with metformin treatment of type 2 diabetes.

This study was performed to define the effect of metformin on glycaemic control and erythrocyte insulin receptor tyrosine kinase activity in patients with non-insulin-dependent (Type 2) diabetes mellitus. A case-control study of the effect of metformin treatment in hyperglycaemic patients with Type 2 diabetes was conducted in outpatients of the Diabetes Clinical Center. The study population consisted of 14 patients with Type 2 diabetes (5 males, 9 females) whose hyperglycaemia was uncontrolled by diet. Patients were treated with metformin 850 mg twice daily for 2 1/2 months. Fasting plasma glucose concentrations decreased from 8.9 to 6.4 mmol/L after 10 weeks of metformin treatment (p < 0.001), in association with significantly lower (p < 0.001) plasma glucose and insulin concentrations in response to an oral glucose load. In addition, both fasting plasma triglyceride and cholesterol concentrations were significantly (p < 0.001) lower after metformin treatment. There was no change in erythrocyte insulin receptor binding associated with metformin treatment, but both basal and insulin-stimulated insulin receptor tyrosine kinase activities of solubilized erythrocyte insulin receptors were significantly higher after 10 weeks of metformin treatment. It is concluded that the increase in insulin-stimulated tyrosine kinase activity contributed to the improvement in glucose insulin and lipoprotein metabolism associated with metformin treatment of Type 2 diabetes.

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