[细胞内pH值对哺乳动物细胞辐射损伤的影响]。

Radiobiologiia Pub Date : 1993-03-01

A A Waĭnson, S M Ershova, I L Lapidus, T A Fadeeva, T E Fomenkova, N L Shmakova

{"title":"[细胞内pH值对哺乳动物细胞辐射损伤的影响]。","authors":"A A Waĭnson, S M Ershova, I L Lapidus, T A Fadeeva, T E Fomenkova, N L Shmakova","doi":"","DOIUrl":null,"url":null,"abstract":"In experiments with Chinese hamster cells and Ehrlich ascites tumor cells it has been shown that a decrease in intracellular pH from 7.0 to 6.0, produced by 0.1 M phosphate buffer, ameliorates the radiation injury to cells (DMF = 1.35) with respect to their clonogenic capacity and induction of chromosome aberrations. The rate of repair of DNA single-strand breaks, within the pH range under study, is invariable.","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":"33 2","pages":"220-4"},"PeriodicalIF":0.0000,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The effect of intracellular pH on radiation damage to mammalian cells].\",\"authors\":\"A A Waĭnson, S M Ershova, I L Lapidus, T A Fadeeva, T E Fomenkova, N L Shmakova\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In experiments with Chinese hamster cells and Ehrlich ascites tumor cells it has been shown that a decrease in intracellular pH from 7.0 to 6.0, produced by 0.1 M phosphate buffer, ameliorates the radiation injury to cells (DMF = 1.35) with respect to their clonogenic capacity and induction of chromosome aberrations. The rate of repair of DNA single-strand breaks, within the pH range under study, is invariable.\",\"PeriodicalId\":20808,\"journal\":{\"name\":\"Radiobiologiia\",\"volume\":\"33 2\",\"pages\":\"220-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiobiologiia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiobiologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

用中国仓鼠细胞和埃利希腹水肿瘤细胞进行的实验表明，0.1 M磷酸盐缓冲液使细胞内pH从7.0降低到6.0，可以改善细胞(DMF = 1.35)在克隆能力和诱导染色体畸变方面的辐射损伤。在研究的pH范围内，DNA单链断裂的修复速率是不变的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[The effect of intracellular pH on radiation damage to mammalian cells].

In experiments with Chinese hamster cells and Ehrlich ascites tumor cells it has been shown that a decrease in intracellular pH from 7.0 to 6.0, produced by 0.1 M phosphate buffer, ameliorates the radiation injury to cells (DMF = 1.35) with respect to their clonogenic capacity and induction of chromosome aberrations. The rate of repair of DNA single-strand breaks, within the pH range under study, is invariable.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Radiobiologiia

自引率

0.00%

发文量