{"title":"睾酮对幼鼠输精管对去甲肾上腺素反应的影响。","authors":"J L Lamas, R C Spadari","doi":"10.1016/0306-3623(93)90032-s","DOIUrl":null,"url":null,"abstract":"<p><p>1. Following in vitro treatment with 12 microM 6-hydroxy-dopamine, 2 microM B-oestradiol, 0.1 microM propranolol and 10 microM cocaine vasa deferentia isolated from young rats (21-23 days old) showed supersensitivity to norepinephrine (NE) compared to those from adult (3 months old) rats. 2. The pA2 values for prazosin were higher in young (9.6 +/- 0.1) than in adult (8.3 +/- 0.1) rat vas deferens, with the slopes of the Schild plots not different from 1.0 (0.78 +/- 0.26 and 1.14 +/- 0.14, respectively). 3. The treatment of young rats with a single dose of testosterone abolished the supersensitivity to NE and the higher affinity for prazosin. 4. We conclude that there is a reduction of neuronal NE uptake and a decrease in the sensitivity to NE in the vas deferens as the rat matures sexually. 5. Testosterone induces a decrease in the sensitivity to NE, probably via an action on the alpha 1-adrenoceptor population and the sympathetic nerve discharge in this organ.</p>","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"24 1","pages":"185-9"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(93)90032-s","citationCount":"9","resultStr":"{\"title\":\"Effect of testosterone on the response of young rat vas deferens to norepinephrine.\",\"authors\":\"J L Lamas, R C Spadari\",\"doi\":\"10.1016/0306-3623(93)90032-s\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>1. Following in vitro treatment with 12 microM 6-hydroxy-dopamine, 2 microM B-oestradiol, 0.1 microM propranolol and 10 microM cocaine vasa deferentia isolated from young rats (21-23 days old) showed supersensitivity to norepinephrine (NE) compared to those from adult (3 months old) rats. 2. The pA2 values for prazosin were higher in young (9.6 +/- 0.1) than in adult (8.3 +/- 0.1) rat vas deferens, with the slopes of the Schild plots not different from 1.0 (0.78 +/- 0.26 and 1.14 +/- 0.14, respectively). 3. The treatment of young rats with a single dose of testosterone abolished the supersensitivity to NE and the higher affinity for prazosin. 4. We conclude that there is a reduction of neuronal NE uptake and a decrease in the sensitivity to NE in the vas deferens as the rat matures sexually. 5. Testosterone induces a decrease in the sensitivity to NE, probably via an action on the alpha 1-adrenoceptor population and the sympathetic nerve discharge in this organ.</p>\",\"PeriodicalId\":12487,\"journal\":{\"name\":\"General pharmacology\",\"volume\":\"24 1\",\"pages\":\"185-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0306-3623(93)90032-s\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"General pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/0306-3623(93)90032-s\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"General pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0306-3623(93)90032-s","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
摘要
1. 幼龄大鼠(21-23日龄)经12 μ m 6-羟基多巴胺、2 μ m b -雌二醇、0.1 μ m普萘洛尔和10 μ m可卡因体外处理后，与成年大鼠(3个月龄)相比，去甲肾上腺素(NE)超敏感。2. prazosin在幼鼠输精管中的pA2值(9.6 +/- 0.1)高于成年大鼠输精管中的pA2值(8.3 +/- 0.1)，Schild曲线斜率为1.0(分别为0.78 +/- 0.26和1.14 +/- 0.14)。3.单剂量睾酮可消除幼鼠对NE的超敏感性和对哌唑嗪的高亲和力。4. 我们得出结论，随着大鼠性成熟，输精管中神经元NE摄取减少，对NE的敏感性降低。5. 睾酮可能通过作用于- 1肾上腺素受体和该器官的交感神经放电而导致对NE敏感性的降低。
Effect of testosterone on the response of young rat vas deferens to norepinephrine.
1. Following in vitro treatment with 12 microM 6-hydroxy-dopamine, 2 microM B-oestradiol, 0.1 microM propranolol and 10 microM cocaine vasa deferentia isolated from young rats (21-23 days old) showed supersensitivity to norepinephrine (NE) compared to those from adult (3 months old) rats. 2. The pA2 values for prazosin were higher in young (9.6 +/- 0.1) than in adult (8.3 +/- 0.1) rat vas deferens, with the slopes of the Schild plots not different from 1.0 (0.78 +/- 0.26 and 1.14 +/- 0.14, respectively). 3. The treatment of young rats with a single dose of testosterone abolished the supersensitivity to NE and the higher affinity for prazosin. 4. We conclude that there is a reduction of neuronal NE uptake and a decrease in the sensitivity to NE in the vas deferens as the rat matures sexually. 5. Testosterone induces a decrease in the sensitivity to NE, probably via an action on the alpha 1-adrenoceptor population and the sympathetic nerve discharge in this organ.
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