[喝酒能预防高原病吗?]

P Bärtsch, S Shaw, P Weidmann, O Oelz
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引用次数: 0

摘要

本文总结了本课题组[2-4]3篇关于高原流体平衡研究的主要成果。57名登山者在22 ~ 77小时内从1170米上升到4559米,其中24人发生急性高原反应(AMS), 16人发生高原肺水肿(HAPE)。14例HAPE患者有AMS症状。在这些研究中,液体摄入量从2升到4升/24小时不等,与摄入相同液体的健康对照组相比,发生AMS的受试者表现出利尿和尿钠减少。较高的液体摄入导致尿量增加,但并不能预防AMS。休息时较高的血浆醛固酮水平和运动引起的血浆醛固酮和血管加压素升高可能解释了AMS患者水和盐潴留增加的原因。这些激素变化是继发于更严重的低氧应激还是AMS的主要原因仍有待确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Does drinking protect against mountain sickness?].

This paper summarizes the main findings of 3 publications of our group [2-4] examining fluid balance at high altitude. Of 57 mountaineers ascending from 1170 m to 4559 m within 22 to 77 hours, 24 developed acute mountain sickness (AMS) and 16 developed high altitude pulmonary edema (HAPE). In 14 cases HAPE was preceded by symptoms of AMS. Independently of the amount of fluid intake, which varied from 2 to 4 l/24 h in these studies, subjects developing AMS showed decreased diuresis and natriuresis compared to healthy controls with similar fluid intake. Higher fluid intake resulted in greater urine output but did not prevent AMS. Higher plasma levels of aldosterone at rest and greater exercise-induced rises of plasma aldosterone and vasopressine may explain the increased water and salt retention in subjects with AMS. Whether these hormonal changes are secondary to a more severe hypoxemic stress or present a primary cause of AMS remains to be determined.

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