[低剂量电离辐射对培养的中国仓鼠成纤维细胞内pH、ATP含量和合成活性的影响]。

Radiobiologiia Pub Date : 1993-01-01
I M Parkhomenko, G V Perishvili, V B Turovetskiĭ, Iu B Kudriashov, A B Rubin, L Iu Brovko
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引用次数: 0

摘要

0.05-0.15 Gy剂量的X射线照射中国成纤维细胞可引起细胞内pH (pHi)变化:在前40-60分钟内降低0.16-0.18个pH单位,照射后120分钟恢复到对照水平,最后增加0.18-0.20个pH单位。同时,细胞的合成活性也发生了同样的变化。而ATP水平的变化则相反:pH值下降时增加,pH值增加时减少。结果表明,pHi的变化与Na+/H(+)交换体系的变化有关,并且它们似乎是所观察到的变化链中的主要变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The effect of low doses of ionizing radiation on intracellular pH, ATP content and synthetic activity in cultured Chinese hamster fibroblasts].

X irradiation of Chinese fibroblasts with doses of 0.05-0.15 Gy was shown to cause intracellular pH (pHi) changes: its diminishing during the first 40-60 min by 0.16-0.18 pH units, then the return to the control level 120 min after irradiation and, finally, the increase by 0.18-0.20 pH units. Simultaneously, the synthesizing activity of the cells changed in the same way. The ATP level changed in the opposite way: increased when pH fell and decreased when pH grew. It was shown that pHi changes were connected with the changes in Na+/H(+)-exchange system, and they seemed to be primary in the chain of the alterations observed.

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