[不同衰减程度土拉菌菌株的糖脂组成]。

Mikrobiologicheskii zhurnal Pub Date : 1993-01-01

V V Sukhar'

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引用次数: 0

摘要

采用硅胶薄层色谱法对土拉菌菌株的糖脂组成进行了研究。与毒株相比，疫苗株缺乏糖脂8，具有新的糖脂8-a和更高水平的糖脂7。低免疫原性菌株的糖脂含量降低，而无毒的非免疫原性菌株(15-a)几乎完全失去糖脂含量。因此，糖脂组成与土拉菌的衰减水平、毒力和免疫原性有关。

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[The glycolipid composition of Francisella tularensis strains with different degrees of attenuation].

The glycolipid composition of F. tularensis strains was investigated by silica gel thin-layer chromatography. Vaccine strains in contrast to virulent ones lacked glycolipid 8, possessed new glycolipid 8-a and a higher level of glycolipid 7. Low immunogenic strains had a decreased content of glycolipids, while avirulent non-immunogenic strain (15-a) nearly completely lost them. Thus, the glycolipid composition is associated with the level of attenuation, virulence and immunogenicity of F. tularensis.

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Mikrobiologicheskii zhurnal

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