{"title":"孤雌生殖胚胎表型分析揭示印迹基因的作用位点。","authors":"S Varmuza, M Mann, I Rogers","doi":"10.1002/dvg.1020140310","DOIUrl":null,"url":null,"abstract":"<p><p>The phenotypes of early post-implantation parthenogenetic embryos were examined. The spectrum of phenotypes suggested that three stages are adversely affected by imprinting--implantation, pregastrulation, and postgastrulation. Survival of parthenogenetic embryos past these developmental blocks can be improved but not completely overcome by experimental asynchrony. These results suggest that imprinting may be \"leaky\" at early stages.</p>","PeriodicalId":11344,"journal":{"name":"Developmental genetics","volume":"14 3","pages":"239-48"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/dvg.1020140310","citationCount":"28","resultStr":"{\"title\":\"Site of action of imprinted genes revealed by phenotypic analysis of parthenogenetic embryos.\",\"authors\":\"S Varmuza, M Mann, I Rogers\",\"doi\":\"10.1002/dvg.1020140310\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The phenotypes of early post-implantation parthenogenetic embryos were examined. The spectrum of phenotypes suggested that three stages are adversely affected by imprinting--implantation, pregastrulation, and postgastrulation. Survival of parthenogenetic embryos past these developmental blocks can be improved but not completely overcome by experimental asynchrony. These results suggest that imprinting may be \\\"leaky\\\" at early stages.</p>\",\"PeriodicalId\":11344,\"journal\":{\"name\":\"Developmental genetics\",\"volume\":\"14 3\",\"pages\":\"239-48\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/dvg.1020140310\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental genetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/dvg.1020140310\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dvg.1020140310","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Site of action of imprinted genes revealed by phenotypic analysis of parthenogenetic embryos.
The phenotypes of early post-implantation parthenogenetic embryos were examined. The spectrum of phenotypes suggested that three stages are adversely affected by imprinting--implantation, pregastrulation, and postgastrulation. Survival of parthenogenetic embryos past these developmental blocks can be improved but not completely overcome by experimental asynchrony. These results suggest that imprinting may be "leaky" at early stages.
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