[高压条件下氦氧混合呼吸对小鼠脂质过氧化和染色体畸变的影响]。

Fiziologicheskiĭ zhurnal Pub Date : 1993-01-01
T P Shkurat, N P Miliutina, A E Nechepurenko, T A Kothcheeva, V M Sapozhnikov, E I Novikova, I V Timofeeva, E I Shimanskaia, B S Dashevskiĭ
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引用次数: 0

摘要

小鼠暴露于氦氧环境(3.6 MPa, 5次)。压缩时间为6 h,等压缩时间为5 d,减压时间为18 h。目前的研究表明,高压氧仅在1和3个疗程后才会增加红细胞膜和血浆中二烯偶联物和移位碱的水平。超氧化物歧化酶在3和5个疗程后被抑制。过氧化氢酶活性保持不变。研究了羟基磷灰石对骨髓、眼角膜和生发组织中染色体畸变的诱导作用。骨髓对高血压更为敏感。诱导骨髓细胞畸变已观察3个月。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Lipid peroxidation and chromosome aberrations in mice after repeated effect of helium-oxygen respiratory mixture in hyperbaric conditions].

Mice were exposed to helium-oxygen conditions (3.6 MPa, 5 sessions). Compression lasted for 6 h, isopression - 5 days, decompression - 18 h. The interval between sessions was 10 days. The present study has revealed that hyperbary increases the level of diene conjugates and shift bases in the erythrocyte membranes and plasma only after 1 and 3 sessions. Superoxide dismutase is suppressed after 3 and 5 sessions. Catalase activity remains unchanged. The effect of hyperbary on the induction of chromosome aberrations in bone marrow, cornea of the eye and germinal tissues has been studied. Bone marrow has been detected as more sensitive to hyperbary. Induction of aberrations in bone marrow cells has observed for 3 months.

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