{"title":"具有时滞的多室模型的平均停留时间","authors":"Y. Plusquellec , G. Houin","doi":"10.1016/0141-5425(93)90121-E","DOIUrl":null,"url":null,"abstract":"<div><p>Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any <em>n</em>-compartmental models which may include time delays. As examples, catenary and mammillary models are considered.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 3","pages":"Pages 240-246"},"PeriodicalIF":0.0000,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90121-E","citationCount":"2","resultStr":"{\"title\":\"Mean residence time in multicompartmental models with time delays\",\"authors\":\"Y. Plusquellec , G. Houin\",\"doi\":\"10.1016/0141-5425(93)90121-E\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any <em>n</em>-compartmental models which may include time delays. As examples, catenary and mammillary models are considered.</p></div>\",\"PeriodicalId\":75992,\"journal\":{\"name\":\"Journal of biomedical engineering\",\"volume\":\"15 3\",\"pages\":\"Pages 240-246\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0141-5425(93)90121-E\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/014154259390121E\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/014154259390121E","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mean residence time in multicompartmental models with time delays
Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any n-compartmental models which may include time delays. As examples, catenary and mammillary models are considered.
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