{"title":"猪卵泡液对颗粒细胞分泌环状GMP的刺激作用。","authors":"J Kolena, A Danisová, L Matulová, S Scsuková","doi":"10.1055/s-0029-1211242","DOIUrl":null,"url":null,"abstract":"<p><p>Effects of FSH, LH and follicular fluid isolated from preovulatory follicles on secretion of progesterone, cAMP a cGMP by cultured immature porcine granulosa cells were investigated. Exposure of granulosa cells to gonadotropins and follicular fluid resulted in increase of progesterone and cGMP formation. Follicular fluid had an inhibitory effect on cAMP synthesis. The findings suggest a possible intermediary role of cGMP for the stimulatory action of follicular fluid in the process of luteinization of granulosa cells.</p>","PeriodicalId":12104,"journal":{"name":"Experimental and clinical endocrinology","volume":"101 4","pages":"262-4"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0029-1211242","citationCount":"4","resultStr":"{\"title\":\"Stimulatory action of porcine follicular fluid on granulosa cell secretion of cyclic GMP.\",\"authors\":\"J Kolena, A Danisová, L Matulová, S Scsuková\",\"doi\":\"10.1055/s-0029-1211242\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Effects of FSH, LH and follicular fluid isolated from preovulatory follicles on secretion of progesterone, cAMP a cGMP by cultured immature porcine granulosa cells were investigated. Exposure of granulosa cells to gonadotropins and follicular fluid resulted in increase of progesterone and cGMP formation. Follicular fluid had an inhibitory effect on cAMP synthesis. The findings suggest a possible intermediary role of cGMP for the stimulatory action of follicular fluid in the process of luteinization of granulosa cells.</p>\",\"PeriodicalId\":12104,\"journal\":{\"name\":\"Experimental and clinical endocrinology\",\"volume\":\"101 4\",\"pages\":\"262-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1055/s-0029-1211242\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and clinical endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0029-1211242\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0029-1211242","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stimulatory action of porcine follicular fluid on granulosa cell secretion of cyclic GMP.
Effects of FSH, LH and follicular fluid isolated from preovulatory follicles on secretion of progesterone, cAMP a cGMP by cultured immature porcine granulosa cells were investigated. Exposure of granulosa cells to gonadotropins and follicular fluid resulted in increase of progesterone and cGMP formation. Follicular fluid had an inhibitory effect on cAMP synthesis. The findings suggest a possible intermediary role of cGMP for the stimulatory action of follicular fluid in the process of luteinization of granulosa cells.