精选天然和合成抗病毒物质的联合作用。2天竺葵多酚复合物与金刚乙胺的体内抗流感活性。

Q4 Biochemistry, Genetics and Molecular Biology

Acta Microbiologica Bulgarica Pub Date : 1993-01-01

G Gegova, N Manolova, Iu Serkedzhieva, V Maksimova, S Uzunov, D Dzeguze, M Indulen

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引用次数: 0

摘要

从天竺葵(Geranium sanguineum L.)中分离的天然产物多酚复合物(polyphenolic complex, PC)与金刚乙胺(rimantadine, R)在体外和卵内结合所显示的协同效应[7]，鼓励我们通过体内试验继续进行这些研究。在感染前6 h以1.0 mg/kg的浓度鼻灌PC与接种前2h、接种后2.24和48 h分别以10.5和2.5 mg/kg的浓度口服R (PI分别为72.55%、55%和57.8%)联合使用，对实验性甲型流感病毒(H3N2)感染小鼠具有显著的保护作用。

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Combined effect of selected antiviral substances of natural and synthetic origin. II. Anti-influenza activity of a combination of a polyphenolic complex isolated from Geranium sanguineum L. and rimantadine in vivo.

The synergistic effect shown by the combination of a natural product, polyphenolic complex (PC) isolated from Geranium sanguineum L., and rimantadine (R) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. A marked protective effect in experimental influenza virus A (H3N2) infection in mice was found when PC was applied nasally (i.n.) (1.0 mg/kg) only once 6 h before infection in combination with R applied orally in concentration 10.5 and 2.5 mg/kg 2h before and 2.24 and 48 h after viral inoculation (PI = 72.55%, 55% and 57.8% respectively).

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来源期刊

Acta Microbiologica Bulgarica Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.40

自引率

0.00%

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