心脏和外周阻力在I组传入纤维对血压反射作用中的作用。

Cardioscience Pub Date : 1994-03-01
G P Orani, M Decandia
{"title":"心脏和外周阻力在I组传入纤维对血压反射作用中的作用。","authors":"G P Orani,&nbsp;M Decandia","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Experiments were done on anesthetized and curarized cats to see whether the increase in blood pressure caused by electrical stimulation of group I afferent fibers is related to a direct reflex effect on the heart. The reflex effect of electrical stimulation of group I afferent fibers from the gastrocnemius-soleus muscles on the arterial pressure, the left ventricular pressure, the inotropic state of the left ventricle (dP50/dt) and the heart rate were compared before and after beta-blockade with propranolol (0.1 mg/kg intravenously) to reduce a possible direct effect on the heart. The same comparison was made before and after alpha-blockade with phentolamine (2.5 mg/kg intravenously) to keep the peripheral resistance constant. Electrical stimulation of group I afferent fibers caused an increase in the blood pressure, the left ventricular pressure and, to some extent, the inotropic state of the left ventricle and the heart rate. The beta-blockade had no significant effect on these increases, while the alpha-blockade abolished the increase in blood pressure. It is concluded that the effect of stimulation of group I afferent fibers on the blood pressure is not dependent on a direct reflex effect on the heart, but can be better explained by a reflex increase in the peripheral resistance.</p>","PeriodicalId":9629,"journal":{"name":"Cardioscience","volume":"5 1","pages":"25-30"},"PeriodicalIF":0.0000,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of the heart and peripheral resistance in the reflex effect of group I afferent fibers on blood pressure.\",\"authors\":\"G P Orani,&nbsp;M Decandia\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Experiments were done on anesthetized and curarized cats to see whether the increase in blood pressure caused by electrical stimulation of group I afferent fibers is related to a direct reflex effect on the heart. The reflex effect of electrical stimulation of group I afferent fibers from the gastrocnemius-soleus muscles on the arterial pressure, the left ventricular pressure, the inotropic state of the left ventricle (dP50/dt) and the heart rate were compared before and after beta-blockade with propranolol (0.1 mg/kg intravenously) to reduce a possible direct effect on the heart. The same comparison was made before and after alpha-blockade with phentolamine (2.5 mg/kg intravenously) to keep the peripheral resistance constant. Electrical stimulation of group I afferent fibers caused an increase in the blood pressure, the left ventricular pressure and, to some extent, the inotropic state of the left ventricle and the heart rate. The beta-blockade had no significant effect on these increases, while the alpha-blockade abolished the increase in blood pressure. It is concluded that the effect of stimulation of group I afferent fibers on the blood pressure is not dependent on a direct reflex effect on the heart, but can be better explained by a reflex increase in the peripheral resistance.</p>\",\"PeriodicalId\":9629,\"journal\":{\"name\":\"Cardioscience\",\"volume\":\"5 1\",\"pages\":\"25-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardioscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardioscience","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

对麻醉和麻醉的猫进行了实验,以观察电刺激I组传入纤维引起的血压升高是否与对心脏的直接反射作用有关。以静脉注射心得安(0.1 mg/kg)阻断β -动脉压、左心室压、左心室肌力状态(dP50/dt)和心率为对照,比较电刺激I组腓肠肌-比目鱼肌传入纤维对动脉压、左心室压、左心室肌力状态(dP50/dt)和心率的反射效应,以减少可能对心脏的直接影响。采用静脉注射苯妥拉明(2.5 mg/kg)阻断α前后比较,保持外周耐药不变。电刺激I组传入纤维引起血压、左心室压力升高,并在一定程度上引起左心室收缩状态和心率升高。β -阻断剂对血压升高没有显著影响,而α -阻断剂消除了血压升高。综上所述,第一组传入纤维的刺激对血压的影响并不依赖于对心脏的直接反射效应,而可以通过外周阻力的反射性增加来更好地解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of the heart and peripheral resistance in the reflex effect of group I afferent fibers on blood pressure.

Experiments were done on anesthetized and curarized cats to see whether the increase in blood pressure caused by electrical stimulation of group I afferent fibers is related to a direct reflex effect on the heart. The reflex effect of electrical stimulation of group I afferent fibers from the gastrocnemius-soleus muscles on the arterial pressure, the left ventricular pressure, the inotropic state of the left ventricle (dP50/dt) and the heart rate were compared before and after beta-blockade with propranolol (0.1 mg/kg intravenously) to reduce a possible direct effect on the heart. The same comparison was made before and after alpha-blockade with phentolamine (2.5 mg/kg intravenously) to keep the peripheral resistance constant. Electrical stimulation of group I afferent fibers caused an increase in the blood pressure, the left ventricular pressure and, to some extent, the inotropic state of the left ventricle and the heart rate. The beta-blockade had no significant effect on these increases, while the alpha-blockade abolished the increase in blood pressure. It is concluded that the effect of stimulation of group I afferent fibers on the blood pressure is not dependent on a direct reflex effect on the heart, but can be better explained by a reflex increase in the peripheral resistance.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信