camp依赖性蛋白激酶催化亚基的晶体结构揭示了蛋白激酶家族的一般特征。

Receptor Pub Date : 1993-01-01

S S Taylor, E Radzio-Andzelm, D R Knighton, L F Ten Eyck, J M Sowadski, F W Herberg, W Yonemoto, J Zheng

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引用次数: 0

摘要

camp依赖性蛋白激酶催化亚基的晶体结构可作为所有真核蛋白激酶催化核心的模板。回顾了各种晶体结构，特别强调了在活性位点聚集的许多保守残基。这些结构也揭示了翻译后修饰的重要性，包括肉豆蔻化和磷酸化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family.

The crystal structure of the catalytic subunit of cAMP-dependent protein kinase serves as a template for the catalytic core of all eukaryotic protein kinases. The various crystal structures are reviewed with particular emphasis on the numerous conserved residues that converge at the active site. The structures also reveal the importance of posttranslational modifications, including myristylation and phosphorylation.

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Receptor

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