{"title":"多发性硬化症的临床试验:一个重要的回顾(1970-1990)。","authors":"R Bergamaschi, A Citterio, G Filippini, V Cosi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The present study is a critical review of 100 papers concerning clinical trials in Multiple Sclerosis (MS), published between 1970-1990. We analyzed 20 validity criteria (internal 12, and external 8) and codified each item as \"adequate\" or \"not adequate\", so that the validity of each report was quantified. In addition, we used a statistical method of automatic classification (cluster analysis) to subdivide all the papers in 4 groups with growing validity. Only 52 reports had a fairly good or good validity, therefore more efforts are suggested to correctly plan clinical trials in MS and lead to reliable results.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 6","pages":"462-74"},"PeriodicalIF":0.0000,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical trials in multiple sclerosis: a critical review (1970-1990).\",\"authors\":\"R Bergamaschi, A Citterio, G Filippini, V Cosi\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present study is a critical review of 100 papers concerning clinical trials in Multiple Sclerosis (MS), published between 1970-1990. We analyzed 20 validity criteria (internal 12, and external 8) and codified each item as \\\"adequate\\\" or \\\"not adequate\\\", so that the validity of each report was quantified. In addition, we used a statistical method of automatic classification (cluster analysis) to subdivide all the papers in 4 groups with growing validity. Only 52 reports had a fairly good or good validity, therefore more efforts are suggested to correctly plan clinical trials in MS and lead to reliable results.</p>\",\"PeriodicalId\":6970,\"journal\":{\"name\":\"Acta neurologica\",\"volume\":\"15 6\",\"pages\":\"462-74\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta neurologica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta neurologica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical trials in multiple sclerosis: a critical review (1970-1990).
The present study is a critical review of 100 papers concerning clinical trials in Multiple Sclerosis (MS), published between 1970-1990. We analyzed 20 validity criteria (internal 12, and external 8) and codified each item as "adequate" or "not adequate", so that the validity of each report was quantified. In addition, we used a statistical method of automatic classification (cluster analysis) to subdivide all the papers in 4 groups with growing validity. Only 52 reports had a fairly good or good validity, therefore more efforts are suggested to correctly plan clinical trials in MS and lead to reliable results.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
