C. Cubría , M. Alvarez-Bujidos , A. Negro , R. Balaña-Fouce , D. Ordóñez
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4',6-diamidino 2-phenylindole is a new reversible inhibitor of diamine oxidase and S-adenosyl-l-methionine decarboxylase from mammalian tissues
1. 4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver decarboxylase.
2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13μM.
3. A similar inhibitory pattern has been found on rat liver decarboxylase with an estimated Ki of 21 μM.
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