{"title":"多卤联苯分子结构与肝微粒体单加氧酶代谢的关系","authors":"J.T. Borlakoglu , J.P.G. Wilkins","doi":"10.1016/0742-8413(93)90066-T","DOIUrl":null,"url":null,"abstract":"<div><p>1. Collation of the data presented in the preceding papers (references 4,5) showed a significant correlation (<em>r</em> = 0.83; <em>P</em> < 0.001) between the molecular mass (and hence the extent of halosubstitution) of halogenated biphenyls and their rate of hydroxylation by hepatic microsomal monooxygenases.</p><p>2. There was no relationship between the extent of poly<em>ortho</em> halosubstitution of biphenyl and the rate of metabolism.</p><p>3. A marginal correlation (<em>r</em> = 0.33; <em>P</em> < 0.001) was found when the number of adjacent unsubstituted <em>meta-para</em> positions were linked to the rate of metabolism of PCBs. This structural feature facilitates microsomal oxidation.</p><p>4. The results support the proposal that PCBs with <em>meta-para</em> hydrogen atoms are less enriched in tissues of animals and humans as this structural feature favours their metabolism by P450 isoenzymes.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 113-117"},"PeriodicalIF":0.0000,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90066-T","citationCount":"25","resultStr":"{\"title\":\"Correlations between the molecular structures of polyhalogenated biphenyls and their metabolism by hepatic microsomal monooxygenases\",\"authors\":\"J.T. Borlakoglu , J.P.G. Wilkins\",\"doi\":\"10.1016/0742-8413(93)90066-T\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. Collation of the data presented in the preceding papers (references 4,5) showed a significant correlation (<em>r</em> = 0.83; <em>P</em> < 0.001) between the molecular mass (and hence the extent of halosubstitution) of halogenated biphenyls and their rate of hydroxylation by hepatic microsomal monooxygenases.</p><p>2. There was no relationship between the extent of poly<em>ortho</em> halosubstitution of biphenyl and the rate of metabolism.</p><p>3. A marginal correlation (<em>r</em> = 0.33; <em>P</em> < 0.001) was found when the number of adjacent unsubstituted <em>meta-para</em> positions were linked to the rate of metabolism of PCBs. This structural feature facilitates microsomal oxidation.</p><p>4. The results support the proposal that PCBs with <em>meta-para</em> hydrogen atoms are less enriched in tissues of animals and humans as this structural feature favours their metabolism by P450 isoenzymes.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"105 1\",\"pages\":\"Pages 113-117\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90066-T\",\"citationCount\":\"25\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/074284139390066T\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390066T","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Correlations between the molecular structures of polyhalogenated biphenyls and their metabolism by hepatic microsomal monooxygenases
1. Collation of the data presented in the preceding papers (references 4,5) showed a significant correlation (r = 0.83; P < 0.001) between the molecular mass (and hence the extent of halosubstitution) of halogenated biphenyls and their rate of hydroxylation by hepatic microsomal monooxygenases.
2. There was no relationship between the extent of polyortho halosubstitution of biphenyl and the rate of metabolism.
3. A marginal correlation (r = 0.33; P < 0.001) was found when the number of adjacent unsubstituted meta-para positions were linked to the rate of metabolism of PCBs. This structural feature facilitates microsomal oxidation.
4. The results support the proposal that PCBs with meta-para hydrogen atoms are less enriched in tissues of animals and humans as this structural feature favours their metabolism by P450 isoenzymes.
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