胃肠癌在共济失调-毛细血管扩张家族中的高发。

Acta neurologica Pub Date : 1994-02-01

M Ceroni, J Karau, P Pergami, D Ferrandi, F Savoldi

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引用次数: 0

摘要

文献表明，共济失调-毛细血管扩张症的纯合子和杂合子都有很高的癌症发病率，可能是由于DNA修复受损。最常见的是与乳腺、肺、膀胱、前列腺和胃肿瘤的关联，而与结直肠癌的关联尚未得到证实。本文报道的影响家族似乎有胃肠道肿瘤的高发，包括结肠直肠肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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High incidence of gastrointestinal cancer in a family with ataxia-telangiectasia.

Literature suggests that not only homozygotes but also heterozygotes for ataxia-telangiectasia have a high incidence of cancer, probably due to an impairment in DNA repair. The most frequent associations are with breast, lung, bladder, prostate and stomach tumors, while no correlation with colorectal cancer has been demonstrated. The affected family reported in this paper seems to have a high incidence of gastrointestinal tract tumors, including the colorectal ones.

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Acta neurologica

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